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Abdallat Davis Farrage syndrome is a rare genetic condition characterized by skin pigmentation irregularities and nervous system problems. It is a recessive trait that can be inherited from both parents and has no known cure. Patients require comfort care, and intermarriage within an extended family increases the risk of passing on the genetic trait.
Abdallat Davis Farrage syndrome is an extremely rare genetic condition that was first identified and described in 1980. It is characterized by skin pigmentation irregularities and nervous system problems. The condition is named after the team of medical professionals who first wrote about it, describing the appearance of the syndrome in a Jordanian family. It manifested itself in two brothers and a sister who were the children of first cousins who had gotten married, suggesting a strong genetic link, and later tests indeed revealed that the condition is genetic in nature.
This condition is a recessive trait, which means that in order to experience symptoms, someone must inherit a gene for Abdallat Davis Farrage syndrome from both parents. It is also autosomal, not linked to any of the genes that determine gender, so it can occur in both men and women. People with only one gene are carriers and typically have no symptoms; in the event that someone inherits both genes, symptoms usually appear before one year of age.
A multitude of symptoms are associated with Abdallat Davis Farrage syndrome, but it is basically classified as a form of phakomatosis, which means it is a disease of the central nervous system that is accompanied by skin abnormalities. It is also known as “neurocutaneous syndrome, Abdallat type”, referring to the neurological and skin problems associated with patients who have inherited both genes for the syndrome.
Skin problems associated with this condition include albinism, spots or uneven pigmentation on the skin, and an increase in freckles. Many patients also exhibit unusual hair color, as part of albinism. The central nervous system problems of patients with Abdallat Davis Farrage syndrome cause them extreme impairment of their extremities, including weakness in the arms and legs known as spastic paraparesis, and they tend to have a lack of pain sensitivity, which can be problematic. Most experience peripheral neuropathy, a slow and steady degeneration of their peripheral nerves.
So far, there is no treatment for Abdallat Davis Farrage syndrome. Patient care usually focuses on keeping them comfortable and allowing them to live as normally as possible. Like other recessive traits, the condition can be evidenced through intermarriage within an extended family. Many countries specifically ban such marriages for this very reason, and in regions where marriage within the family is not banned, people may want to think carefully about the consequences of a cousin marriage, as it greatly increases the risk of passing on genetic traits dangerous.
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