Estradiol and cancer: any link?

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Estradiol, a hormone, can increase the risk of cancer by promoting malignant growth of breast cells, especially when there is an abundance of insulin in the body. Estradiol triggers the expansion of certain breast cells that have estrogen receptors, which can lead to cancer. The hormone is necessary for female development, but cancer risks arise when there is too much in the body, caused by medicines, birth control, cosmetics, and even some meats and milk. Anti-estrogen medications can help fight the link between elevated estradiol and cancer.

Scientific research has established that there is a causal relationship between estradiol and cancer, with estradiol, a hormone, increasing the risk of cancer by promoting malignant growth of breast cells. This negative causal relationship is more likely when there is an abundance of insulin in the body. Scientists have discovered that estradiol, a form of estrogen, specifically triggers the expansion of certain MCF-7 breast cells that have estrogen receptors (ERs). Researchers believe that these ER-positive cells, when stimulated, trigger a cycle of cell growth that is unwarranted unless there is an absence of insulin. Without insulin and without estrogen receptor cells, estradiol may not trigger the growth of malignant cells, according to research.

The connection between estradiol and cancer may be the result of more than just estradiol’s ability to cause cells to synthesize DNA and begin to proliferate. Scientists believe that oxygen radicals are another key factor in estradiol becoming a real cancer risk. Studies have long indicated that oxygen free radicals can lead to cancer by damaging otherwise healthy cells; estradiol, according to studies, is dangerous because it can produce its own oxygen free radicals in ER-positive cells. Although estradiol is primarily linked to breast cancer, it can also cause cancer of the uterus and endometrium.

In normal amounts, estradiol and cancer are unrelated. Estradiol is actually necessary and beneficial for women because it governs proper female development. For example, estradiol, which is naturally produced every day in the female body, drives the development and maintenance of a woman’s uterus, breasts, and fallopian tubes. This steroid hormone also regulates the way fat is deposited on a woman’s body, driving the shape of her figure. Along with two other forms of estrogen – estriol and estrone – estradiol helps regulate female menstruation and pregnancy.

Cancer risks arise when there is too much estradiol in the body; sometimes this is caused by medicines that contain estradiol from other animal sources. This therapeutic estradiol supplementation is often part of female hormone replacement therapy for conditions such as menopause. The hormone may also be present in some forms of birth control and some cosmetics. These environmental and medical exposures increase the risk of women encountering the dangerous link between estradiol and cancer.

Also, because estradiol is occasionally used in some veterinary medicines, traces of the hormone can end up in some meats and milk, according to some medical reports. The link between elevated estradiol and cancer can be fought with anti-estrogen medications. Doctors have found that some steroidal anti-estrogens can stop estradiol cancer from growing and even prevent it altogether.




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