Leptin resistance: what is it?

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Leptin resistance occurs when the body becomes intolerant to the hormone leptin, which can lead to ongoing feelings of hunger and overeating, and increase the risk of obesity, diabetes, and heart disease. Chronic overeating and advancing age may contribute to leptin resistance, but regular fat burning exercises can help reduce leptin levels.

Leptin resistance usually occurs when the body develops an intolerance to the hormone leptin. Fat cells in the body normally produce this hormone. When the body is appropriately sensitive to leptin, the hormone can help prevent obesity by signaling to the brain that the stomach is full after a meal. People who suffer from leptin resistance usually don’t interpret these neural signals correctly, or they may be experiencing reduced numbers of leptin receptors in the brain, which is often a normal result of the aging process. Leptin resistance can prevent the brain from recognizing that the stomach is full, leading to ongoing feelings of hunger and overeating. Leptin resistance typically leads to the development of abdominal fat, which can increase the risk of obesity, diabetes, and heart disease.

Chronic overeating can cause leptin resistance because it can cause the buildup of fatty tissue in the body. Fat cells produce leptin, so the more fat cells a person’s body has, the more leptin that person’s body produces. When the brain is flooded with high levels of leptin, it can start to ignore the hormone’s signals. Some experts believe that the cycle of overeating, weight gain, overeating, and continued weight gain begins this way. More fat cells produce more leptin, which leads to increased stamina and increased weight gain.

Some researchers believe that high leptin levels in the body may impair the hormone’s ability to function properly. Others believe that advancing age may contribute to leptin resistance. The brain’s leptin receptors can naturally decrease in number as the body ages. This can inhibit the brain’s ability to receive appropriate signals for the fullness of leptin action. This may be why weight gain becomes more likely as one ages.

Leptin is considered crucial for the prevention of overeating, weight gain, and obesity, because it generally tells the brain when the stomach is full. Feelings of fullness and satiety occur, and the person probably stops eating. When the brain doesn’t receive the proper satiety signals due to leptin resistance, feelings of hunger are likely to continue even after the stomach is full. As a result, they are likely to overeat and gain weight.

Most experts believe that leptin resistance can be decreased with regular fat burning exercises. Eliminating body fat can help reduce leptin levels, to break the cycle of overeating and weight gain.




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