Acetoacetic ester synthesis is a versatile reaction used to produce alpha-substituted acetones. Ethyl acetoacetate is deprotonated and alkylated by an electrophile, followed by hydrolysis and decarboxylation. The reaction is based on the special chemistry of carbonyl compounds and can be performed with a variety of electrophiles. The resulting product is useful for the synthesis of […]
Acetoacetic acid is a beta-keto acid produced by the liver and kidneys from fatty acids. It can be used to produce energy for the heart and brain, but an overabundance of ketone bodies can lead to ketoacidosis, a life-threatening condition. Diabetes, glycogen storage disease, hyperthyroidism, and dietary disruptions can cause overproduction of acetoacetic acid. Acetoacetic […]
