Pertussis toxin is a large protein produced by Bordatella pertussis, causing whooping cough. It disrupts intracellular signaling mechanisms, facilitating bacterial colonization. The A/B toxin has six subunits, with S1 having enzymatic activity and S2-S5 binding to receptors on the host cell membrane. The toxin impairs intracellular signaling by adding ADP-ribose to G protein, interfering with […]
Bordetella pertussis causes whooping cough, which was once a deadly disease but is now rare thanks to vaccination. The bacterium colonizes the airways and generates toxins that weaken the immune system and cause a severe cough. Treatment involves antibiotics and support, and infected individuals should avoid contact with vulnerable people. Bordetella pertussis is a bacterium […]
