Pyrogens are proteins that can cause fever by triggering immune reactions. They can be endogenous or exogenous, and exposure to them can be dangerous. Pyrogens act as cytokines in the body and can cause permanent damage or even death. Contaminated drugs can be a source of pyrogens, and rigorous filtration and testing are required to […]
Pyrogen testing detects bacterial toxins in drugs and vaccines that can cause fever in humans. The traditional method involves injecting rabbits with drugs to see if they develop a fever, while a newer test uses horseshoe crab blood. Pyrogenic endotoxins can cause high fever, shock, and death when injected into the bloodstream, and the Limulus […]
