Recombinant antibodies are produced by inserting DNA fragments into organisms using recombinant DNA technology. They can be used for medical research and pharmaceutical development. Companies sell them, and they can be used to treat diseases and identify reactive antigens. Controlled conditions are required for production.
A recombinant antibody is an antibody produced by the use of recombinant DNA technology by inserting a DNA fragment into a yeast, virus or bacterium. The resulting recombinant organism will express the antibody even if it is from a different species. A researcher can collect antibodies for medical research and experimentation. It is also possible to use them in the preparation of pharmaceutical compounds for the treatment of various diseases.
Recombinant DNA technology requires a laboratory environment where researchers can work with a variety of organisms and vectors. The vector acts as a carrier for the DNA of interest. The researcher can select the most appropriate organism and vector based on the genetic material and past successes or failures. It carefully inserts the DNA into the organism’s DNA to force it to clone and express the antibody. Under controlled conditions, it can breed multiple generations of organisms that will all produce the recombinant antibody.
Some scientific companies produce and sell recombinant antibodies. Researchers who want to work with them but don’t have the technology to create them can place an order for a standard or customized product. The company will produce the organisms and send a finished product to the scientist. It can also work for a researcher who wants to develop a new recombinant antibody or who needs a customized product for a very specific need.
These antibodies can be invaluable for pure research as well as pharmaceutical research and development. It may be possible to use recombinant antibodies in antigen screens, to identify reactive antigens in a sample. They can also be useful for treating disease. A patient may take a recombinant antibody to fight an organism that her body cannot identify and isolate on its own. This is an approach to cancer treatment, where patients take drugs that target the cancerous cells and leave the rest alone.
Very controlled conditions are required for the production of recombinant antibodies. The researcher must ensure that the DNA fragment is complete and comes from the correct section of the genome. If it is wrong or there is an error in the DNA, the resulting antibodies may not be usable or may behave unexpectedly. The introduction of contaminants can also cause problems with antibody production, as organisms may make the wrong substance or may not thrive due to accidental DNA insertion. Researchers routinely test the output of their labs to confirm that it is pure and usable.
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