Sequestration is a bone disease caused by dead bone separating from living bone, resulting in tissue loss. Bones are living organs that adapt to external influences and are susceptible to diseases such as sequestration and necrosis, which can occur due to injury, infection, or lack of blood supply. Symptoms include pain, decreased movement, and possible gangrene. Treatment aims to prevent further bone loss and tissue death.
Sequestration is a bone disease that occurs when a piece of dead bone separates from living bone, usually as a result of injury or disease. The process by which dead bone is removed is called necrosis and results in tissue loss. Bone necrosis occurs after a piece of bone dies and then separates. Although the sequestration causes dead bone to separate from living bone, the dead bone often remains partially enclosed or in close contact with the newly formed bone, resulting in a narrow sinus or socket.
There are normally 206 bones in the human body, all of which perform one or more of three main functions. Some bones, such as the skull and rib cage, function to form a protective barrier around certain structures and organs. Other bones, such as the spine, act to support weight and posture. Specific bones are also involved in movement. These include the bones found in the feet, hips and hands.
Bone is not a permanent structure in the body. It is a living and dynamic organ that constantly adapts to mechanical, chemical and external influences. It is the body’s largest storehouse of calcium and phosphate, minerals that are vital to numerous bodily processes.
Like all other organs in the body, bones are susceptible to disease. Seizure is one of many bone disorders and is the death of a bone or cell resulting in tissue damage. This bone disorder can occur due to infections such as osteomyelitis or injuries such as bone fractures. The seizure takes place in localized regions of the body.
Necrosis is the secondary process of cell death, resulting in tissue loss. This process is commonly a result of traumatic injury, bacterial infection, or a condition called ischemia. The term “ischemia” refers to lack of blood or lack of circulation to a particular part of the body. Absence of blood can occur due to a spasm, contraction or blockage of the arteries, also known as thrombosis.
It is usually about 12 hours after the death of a bone or cell body that tissue damage or necrosis begins to occur. In these early stages, there are no symptoms. When symptoms begin, they usually appear in the form of pain, decreased movement, and the possible development of gangrene as a result of decreased blood supply. The tissue damage is permanent, and treatment is used to prevent further bone loss and tissue death, rather than cure the condition completely.
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