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Beta Sitosterol is a plant sterol that lowers cholesterol levels by inhibiting its absorption in the intestine and reducing oxidation capacity. It has antioxidant qualities, may prevent cancer, reduce prostate enlargement, improve urine flow, and support the immune system. It is found in various natural sources and fortified dietary sources.
Beta Sitosterol is a type of phytochemical, classified as a sterol, that occurs naturally in many plants as a component of cell membranes. Its chemical composition is very similar to that of cholesterol with the exception of containing an extra ethyl group. Unlike cholesterol, however, it does not contribute to the formation of arterial plaque. In fact, this substance has been shown to lower serum cholesterol levels in humans. There is also some clinical evidence to suggest that this plant sterol may have additional medicinal benefits.
In terms of its ability to reduce cholesterol levels in humans, beta sitosterol has two different effects in the body. First, it should be noted that plant sterols promote the production of cholesterol in the liver, just like animal fats do. However, this plant sterol reduces the circulation of cholesterol in the blood by inhibiting its absorption in the intestine by up to 50 percent. The second part of the cholesterol-lowering process is observed in the reduced oxidation capacity of low-density lipoproteins, which would otherwise lead to the synthesis and accumulation of LDL cholesterol, the “bad” type.
While beta sitosterol is primarily known for its cholesterol-lowering properties, it has also been studied for its antioxidant qualities. In this regard, this substance has been shown to stimulate the production of certain enzymes capable of protecting cells from oxidative damage due to free radicals. Other studies indicate that beta sitosterol may play a role in preventing the development of certain types of cancer, especially colon, prostate and breast cancer. In fact, in vivo experiments have shown that this substance promotes apoptosis (death) in cancer cells, leaving healthy cells intact. The mechanism underlying this effect is thought to arise from the regulation of protein phosphatase A2 activity.
Researchers have also found that beta sitosterol can help reduce prostate enlargement, as well as improve the volume and speed of urine flow. This substance is also being studied for its potential application in the management of chronic inflammatory conditions. Further studies have focused on the immune-supporting properties of this plant sterol as initial trials have shown that it increases lymphocyte production and natural killer cell activity in humans.
Natural sources of beta sitosterol include wheat germ, rice bran, saw palmetto, avocados and some shrubs, such as sea buckthorn. It is also found in black cumin seeds, pumpkin seeds, flax seeds, peanuts and soybeans. Fortified dietary sources include corn oil and margarine.
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