Biochemical pharmacology studies how drugs affect living systems using live animal test subjects and animal or human tissue organs. It involves molecular pharmacology and supporting sciences like biophysics and biochemistry. The direct effect of drugs on cell reproduction and health is determined before release. The European Society of Biochemical Pharmacology and its journal were created in the 1950s. The society merged with Drug Metabolism Workshops in 1984 and was incorporated into the International Society for the Study of Xenobiotics in 2007.
Biochemical pharmacology is a branch of pharmacological research that studies how drugs affect living systems. This is done using live animal test subjects and animal or human tissue organs and components. It may also involve elements of molecular pharmacology, where the study of protein interaction with drug molecules is used to determine how a drug will act within a cell. Many supporting sciences are used in biochemical drug research, including biophysics and biochemistry, and the study of mammalian cell structure and physiology.
Pharmacological research is focused on determining the direct effect a drug has on cell reproduction and health before it is released into the general population. This leads to the creation of many experimental drugs in the laboratory that are not meant for the eventual treatment of disease, but are instead created primarily to test their reactions with normal biological processes. Attention to the direct biochemical effect of a drug on the human body began in the 1950s.
Research in biochemical pharmacology often involves other disciplines in pharmacology as well. For this reason, international research organizations and journals in the field also welcome and publish articles by researchers in pharmacology and behavioral and physiological toxicology. This often involves cancer research and a focus on the immune system through immunopharmacology. Any research involving the various systems of the body that relate to drug interactions, from the respiratory to the cardiovascular or gastrointestinal systems, can have a direct effect on the results of biochemical pharmacology.
The European Society of Biochemical Pharmacology (ESBP) and its scientific journal Biochemical Pharmacology were created in the 1950s to further research into drug interactions with biological systems, and the ESBP initially had only about 150 members. The ESBP merged in 1984 with Drug Metabolism Workshops (DMW). These are groups of industrial and academic pharmacologists who sometimes conduct research under the leadership of the International Union of Basic and Clinical Pharmacology (IUPHAR) linked to the World Health Organization (WHO).
Since 1970, drug metabolism seminars have been conducted in European, Asian, and North American countries every few years. Each seminar focused on one or more unique aspects of the study of biochemical pharmacology. Examples include in vitro drug metabolism in laboratory vessels to enzymology, which deals with the biochemistry of enzyme actions.
A further move to expand global partnerships in biochemical pharmacology resulted in the ESBP also being incorporated into the International Society for the Study of Xenobiotics (ISSX) in 2007. Xenobiotics are characterized by chemicals, such as drugs, that are inherently foreign to a living organism. As of 2011, the ISSX had an international membership base of more than 2,200 professional members involved in the study of xenobiotics from more than 50 different countries
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