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Clinical biostatistics is the application of biostatistics in clinical trials, from study planning to data analysis. It combines biology and mathematics, and is used to develop study subjects, randomize participants, collect data, and interpret evidence. Statistical analysis is important to determine whether results are statistically significant. Specialized companies and clinical biostatisticians can be used for data interpretation and evaluation.
Clinical biostatistics is a facet of science that involves the application of biostatistics in clinical trials. Clinical trials are designed to be scientifically rigorous, so that the data generated in such trials are meaningful, useful to other scientists, and accepted by the wider scientific community. A large part of the success of clinical trials is the application of clinical biostatistics, which plays a role in everything from the early stages of study planning to data analysis.
Clinical biostatisticians often hold advanced degrees in biostatistics and may have focused specifically on clinical biostatistics during the course of their study. This field combines biology and mathematics, with people using statistical techniques to collect, interpret and understand scientific data. Several software manufacturers have developed programs used in clinical biostatistics, with features that have been designed to meet the specific needs presented by clinical trials.
During the planning phases of a clinical trial, clinical biostatistics is used to develop an appropriate pool of study subjects and to randomize study participants to create a blinded study. Randomization is seen as an important part of clinical trials, as it allows researchers to compare the performance of different groups that were randomly, rather than deliberately, created. Biostatistics software can be used to collect data once the trial begins, and during the data analysis phase, clinical biostatistics comes into play as the evidence is interpreted and discussed.
Statistical analysis is an important part of clinical trials as it allows researchers to determine whether or not their results were statistically significant. For example, anecdotal evidence from a study of a new antibiotic might suggest that the antibiotic was effective, but a statistical review of study participants might show that the placebo was equally effective or that there were serious side effects in many studies. participants that the antibiotic would not be considered a viable treatment by the medical community.
Specialized companies offering biostatistics services can be used by laboratories to interpret their data. Using third-party analytics can validate results, ensuring that the statisticians involved are neutral parties, and can also allow researchers to explore complex statistical models and other options that may not be available to them. Researchers may also keep clinical biostatisticians on staff for the purpose of evaluating ongoing clinical trials. Clinical biostatistics is also sometimes used in the field of epidemiology, where a biostatistician can make sense of data that might otherwise be overwhelming.
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