D-chiro-inositol is a substance found in cell membranes that helps transport fat and regulates appetite. It occurs naturally in certain foods and can be used to treat polycystic ovary syndrome (PCOS) and depression. Studies have shown a connection between D-chiro-inositol and insulin resistance, and supplementation has improved insulin levels and ovulation in women with PCOS. However, high doses can cause gastrointestinal disturbances, and patients should consult with their doctors before using inositol.
D-chiro-inositol is one of nine forms of a substance in cell membranes useful for transporting fat from the liver. It also signals molecules in the body to release serotonin in the brain, which could promote a sense of well-being and regulate appetite. D-chiro-inositol occurs naturally in various foods and could be used to treat polycystic ovary syndrome (PCOS) and depression.
Researchers found a connection between D-chiro-inositol and insulin resistance in several studies. Women with PCOS who were resistant to insulin showed improvement in both conditions after D-chiro-inositol supplementation. Insulin levels improved in some study participants, and some women began to ovulate.
PCOS represents a common disorder in women when numerous small cysts grow under the surface of the ovaries. Doctors believe that cysts form when the egg follicles do not develop properly due to hormonal imbalances. This disorder tends to run in families and can cause infertility problems. Irregular menstrual cycles are a common sign of this condition.
Patients with insulin resistance experience problems digesting carbohydrates and sugar at a normal rate, causing blood sugar levels to rise. The scientists found D-chiro-inositol deficiencies in patients diagnosed with type two diabetes. One study using supplements of the agent improved insulin levels.
A form of inositol called myoinositol is used to treat obsessive-compulsive disorder and depression. D-chiro-inositol uses myo-inositol as its base and might also help treat anxiety disorders and depression. Experts caution against combining these supplements with prescription drugs used to treat these disorders, which could increase episodes of manic behavior in bipolar patients and increase the effects of prescription drugs.
D-chiro-inositol occurs in certain foods, including brown rice, wheat germ, liver, and legumes. It is also present in lesser amounts in buckwheat, oats, oranges, peanuts, and whole wheat flour. Those who prefer to obtain the substance through natural or synthetic supplements generally take between 200 milligrams and 500 milligrams per day.
Supplements of the metabolite are considered expensive by some people, who choose to substitute another form of inositol instead. Studies using other forms have shown some promise in the treatment of PCOS by slightly increasing ovulation. Some women who participated in this research gained weight, while others lost it. A combination of diet and supplements may be effective for some patients.
Side effects of the substance in high doses include gastrointestinal disturbances such as diarrhea and nausea. Safety information on the long-term effects of using these supplements has been scant. Patients with insulin resistance and PCOS should consult with their doctors before using inositol.
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