Mechanical growth factor (MGF) is a type of growth factor that enters muscle fibers to repair skeletal muscle tissue and prevent damaged cell death. It is triggered by rigorous exercise and muscle damage and differs from insulin-like growth factor-1 (IGF-1) in its structure and release signals. MGF supplements have limited effectiveness for older people due to a decrease in response to the growth factor. Injecting MGF directly requires the use of polyethylene glycol to protect the protein structure, but supplements should be used wisely as they only increase muscle mass in the local area where they are injected.
Mechanical growth factor (MGF) is a variation of insulin-like muscle growth factor-1 (IGF-1) triggered by rigorous exercise and muscle damage. Structurally different from other growth factors such as IGF-1 which is synthesized by the liver, MGF enters muscle fibers to repair skeletal muscle tissue and prevent the death of damaged cells. It adds stem cells into the muscle and is triggered by a stimulation pulse after the muscle tissues have been subjected to significant mechanical stress. The genes for FGM are transcribed to a lesser extent as people age, which is why muscle mass decreases in the elderly, and some diseases also interfere with its production. Supplements don’t work as well for older people due to the decrease in response to mechanical growth factor.
The difference between mechanical growth factor and IGF-1 is that a group of carbon molecules at the end of the protein, called the C-terminus, controls the release of signals that activate secretion. When muscles are damaged, MGF is activated, triggering the formation of additional proteins and allowing the nuclei of healthy muscle cells to form into new muscle tissue and fibers. A more systemic type of insulin-like growth factor by the liver is also produced in larger quantities, aiding the long-term muscle repair process.
Damaged muscles need to be repaired locally so that damaged cells do not die and lead to further degradation. The release of stem cells regenerates the muscle and the process is very specific because the contracting elements, energy sources, nuclei and fluid in the muscle cells, which make up the fibers, also need to be replenished. A lack of growth hormone can lead to deficiencies in mechanical growth factor. HRT, however, can trigger the release of MGH to help older adults maintain muscle tone and benefit from exercise to some extent.
Bodybuilders have tried injecting mechanical growth factor directly. Doing this doesn’t have much effect because the substance degrades very quickly. To allow the MGF to survive long enough, another substance called polyethylene glycol is injected, which protects the protein structure so that the mechanical growth factor is activated when weightlifters and other people undergoing rigorous exercise stress the their muscles. Polyethylene glycol is used with many pharmaceutical products to deliver drugs to specific areas of the body as well. Used for many purposes, MGF supplements should be used wisely, because only the local area where they are injected will increase muscle mass, but within a matter of weeks.
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