Phenylalanine is an amino acid found in food and used to make proteins. It can be taken as a supplement, but high amounts can be toxic. People with phenylketonuria (PKU) cannot break down phenylalanine, causing brain damage. PKU can be prevented through newborn screening and a low-phenylalanine diet.
Phenylalanine is an amino acid, commonly found in food, that the body uses to make proteins. Phenylalanine is sometimes taken as a dietary supplement. It is believed to have the potential to relieve pain and depression, among other things. People with phenylketonuria (PKU) do not have the ability to break down this amino acid, causing it to accumulate and cause brain damage. PKU is a rare inherited genetic disorder.
Like the other 19 or 20 amino acids, phenylalanine is a nitrogen-containing molecule. It is made up of an amine group and a carboxyl group, and an identifying side chain. The side chain in this case is a phenyl group. It is an essential amino acid, which means that it cannot be produced by the body and must be obtained from the diet.
As a supplement, phenylalanine is often taken in a form that also incorporates a close chemical cousin. Certain supplementary preparations can have complex effects on the body, so medical guidance is recommended. Phenylalanine has been studied in relation to health conditions such as depression, general and specific pain, and Parkinson’s disease. Most people are not deficient in phenylalanine due to its widespread presence in healthy diets. High amounts of supplements can lead to toxicity, and people with PKU should never take phenylalanine supplements.
PKU is a genetic disorder that results from an inability to convert phenylalanine to the amino acid tyrosine. In people who have PKU, phenylalanine accumulates in the brain, where it can cause serious damage such as mental retardation. In most developed countries, screening for the condition at birth can prevent or greatly reduce the harmful effects of this disorder. This is because the greatest amount of damage occurs in the first few days after birth. Although adults seem less vulnerable to nerve damage, lifelong dietary restrictions have been found to be helpful in managing the condition.
Phenylalanine is found in most protein-containing foods, making it difficult to avoid. People with PKU must follow a strict and often complex diet low in phenylalanine to avoid complications of the disorder. The help of a doctor and dietitian is an important factor in designing and following such a restricted diet. People with PKU should not consume artificially sweetened aspartame products, some of which have PKU warning labels. This is because aspartame is made by combining phenylalanine with another amino acid.
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