Progestogen is a synthetic hormone used for contraception, hormone replacement therapy, and treating disorders of the uterus. It is more effective than natural progesterone when taken orally and is used to balance estrogen replacement in HRT to prevent medical complications. Progestin was created to offer the benefits of progesterone therapy without its drawbacks.
Progestogen is a synthetic hormone similar to natural progesterone. It has a number of pharmaceutical applications, but is most often used for contraception or hormone replacement therapy. There are many different forms of progestin, including medroxyprogesterone, noretinodrel, and levonorgestrel.
In contraception, progestogen can be combined with estrogen, while in HRT it is used to balance estrogen replacement to prevent medical complications. Progestin is also used to treat disorders of the uterus, including amenorrhea or abnormal lack of menstruation, dysfunctional uterine bleeding, and endometriosis, in which cells similar to those lining the inside of the uterus grow outside the uterus. uterus, causing pain and often infertility. Additionally, it may help relieve symptoms of endometrial or uterine lining, kidney, breast, and prostate cancer. Progestogens are also sometimes used to support the mother’s hormone production in IVF and to prevent premature birth or miscarriage in women with a history of both conditions. However, progesterone is often used for such applications in place of the progestin.
Progestin was created to offer the benefits of progesterone therapy without its drawbacks. When a woman is pregnant, her body releases progesterone, which prevents her from ovulating. The hormone is therefore an effective form of birth control, as it can trick the body into thinking it is pregnant and prevent ovulation. However, progesterone has low bioavailability when taken by mouth, which means the body doesn’t absorb it well. If the hormone is injected, the bioavailability problem is circumvented, but progesterone tends to cause irritation at the injection site.
Progestin is much more effective than progesterone when taken by mouth. The first progestin, ethisterone, was synthesized in 1938 by Hans Herloff Inhoffen, and many other versions would follow. The first oral contraceptive, Enovid, contained noretinodrel as the active ingredient. It was approved as a contraceptive by the US in 1960 and by the UK a year later. Prior to 1960, Enovid and similar hormone treatments were used only for menstrual disorders.
In hormone replacement therapy, which relieves symptoms associated with the body’s decreased hormone production during menopause, progestogens are used to balance the replacement of estrogen. If estrogen is used alone, complications can occur including abnormal proliferation of endometrial cells, a condition called endometrial hyperplasia. If left untreated, it can lead to endometrial cancer.
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