Propionyl-L-carnitine is an amino acid that can be taken as a supplement or administered intravenously to treat conditions such as erectile dysfunction, heart disease, and poor circulation. It may also be used for chronic fatigue syndrome, congestive heart failure, and Peyronie’s disease. Side effects may include a “fishy” odor, stomach pain, and chest pain. Patients should disclose all medications and medical conditions to their doctor before use.
Propionyl-L-carnitine is a type of amino acid, which is a component of proteins. Amino acids occur naturally in the body; However, some people can also take supplements. Patients with erectile dysfunction (ED) and blood circulation problems can take propionyl-L-carnitine. A doctor can also administer this amino acid intravenously to treat heart disease, blood vessel disorders, and angina, or chest pain. Those with leg pain, or intermittent claudication, caused by peripheral vascular disease (PVD) or poor circulation in the legs may also benefit from this treatment.
Other medical conditions that propionyl-L-carnitine may be used for may include chronic fatigue syndrome (CFS), congestive heart failure, and Peyronie’s disease, as well as inadequate testosterone levels. It is often prescribed along with medications. The supplement works by helping the body produce energy and possibly increase blood circulation. This amino acid is essential in many processes in the body, including muscle movement and the proper functioning of the heart.
A patient’s dose of propionyl-L-carnitine will vary, depending on the condition being treated. People with Peyronie’s disease can take 2 grams (g) a day, and men who have abnormally low testosterone levels can take the same amount daily, along with another amino acid called acetyl-L-carnitine. Patients with blood circulation problems, angina, or congestive heart failure may receive 500 milligrams (mg) three times a day. People with a blood vessel disorder can take between 500 and 1,500 mg twice a day. Some people can use the oral form of this supplement, while others, such as those with blood vessel disorders, must receive the amino acid intravenously or directly into a vein.
Some side effects can occur while using propionyl-L-carnitine; however, it is generally a safe supplement for many patients. Possible side effects can include a “fishy” odor that is noticeable in a person’s sweat, urine, and breath. Stomach pain, nausea, and vomiting have also been reported, and occasionally, chest pain or weakness may occur.
Before using propionyl-L-carnitine supplements or intravenous therapy, patients should disclose all other medications and supplements they are taking. This treatment can interact with other medications, including blood thinners such as warfarin and acenocoumarol. Those taking this supplement along with a blood thinner may be at increased risk of unusual bruising or bleeding, and may require a dose adjustment.
Patients should also discuss their other medical conditions with their doctors. Pregnant or lactating women should not use this treatment. People with a history of seizures may be at higher risk of worsening or more frequent seizures. Propionyl-L-carnitine can also worsen hypothyroidism, or an underactive thyroid.
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