What’s tubular adenocarcinoma?

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Tubular adenocarcinoma is a cancerous tumor with glandular properties. Definitive diagnosis requires a tissue biopsy, as some growths may be benign tumors or adenomas. Growths can appear in any organ. Depending on the location, patients can have the growths for years without experiencing symptoms.

The abnormal cells typically grow in the epithelium. Cancerous lesions often show a distinct periphery and have different pigmentation than surrounding healthy cells. The tissue overlying the cancer may appear shriveled. The cells may or may not develop from glandular tissue, but they often produce gland-like tubular cells that produce mucin. A tissue biopsy usually provides a positive diagnosis.

Staging cancerous growths generally involves assessing the level of glandular formation within the structure. Pathologists evaluate cellular characteristics and the amount of abnormal cell reproduction. The presence and amount of tissue necrosis and solid material within the tumor are also determining factors. Doctors usually describe tubular adenocarcinoma as being in one of three stages: well-differentiated, moderately, and poorly differentiated.

Well-differentiated tubular adenocarcinoma typically contains well-formed glands throughout the structure, and the cells may appear similar to healthy tissue. Moderately differentiated tumors may contain a combination of well and underdeveloped glandular cells. Poorly differentiated tumors may lack glandular cells, and those that are present usually appear extremely bumpy. These advanced tumors also have a combination of single and clustered cells.

In the gastrointestinal tract, tubular adenocarcinoma can occur as a result of chronic conditions including Chron’s disease, esophageal reflux, and ulcers. Repeated tissue injuries and repairs are thought to contribute to any abnormal tissue formation. Studies indicate that tubular adenocarcinoma in the lungs is the most common form of lung cancer in non-smokers and women. Lesions tend to develop on the periphery and do not produce the typical chronic cough or cough that produces blood.

Tubular adenocarcinoma makes up 1%-2% percent of breast cancers. When diagnosed correctly, this type of breast cancer has an excellent prognosis, as it rarely metastasizes. Tubular adenocarcinoma can also develop in the kidneys, thyroid or reproductive organs.

Chemotherapy, radiation therapy, and surgery are all options for treating tubular adenocarcinoma, and biological and hormonal therapies are also available. The method or methods of treatment generally depend on the size and location of the cancer, although the patient’s age and health are also taken into consideration. Because many conventional treatments destroy both healthy and cancerous tissue, patients usually require medication for side effects.

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